IVIG Shows Promising Results in Immunological Infertility and Recurrent Implantation Failure – Dr Nisarg Patel and raises hopes in infertile patients


Intravenous immunoglobulin (IVIG) therapy has emerged as a promising treatment option for couples struggling with infertility and recurrent implantation failure. If immunological issues are one of the reasons, amongst other factors leading to infertility, then Intravenous immunoglobulin (IVIG) therapy should be given a serious thought.

Dr Nisarg Patel of Nisha IVF, one the leading IVF specialists in Ahmedabad, states, “IVIG is the new ray of hope for patients with immunological infertility and recurrent implantation failure. I have successfully treated patients whose immunological factors have been identified as contributing factors to infertility or implantation failure. Hence, IVIG treatment has to be taken under the guidance of a qualified IVF expert who has accurately diagnosed immunological factors as the reason for infertility.” 

To understand IVIG, we must understand the reasons for immunological infertility and recurrent implantation failure. Immunological fertility occurs when a woman’s immune system considers the embryo a foreign invader and attempts to destroy it, leading to miscarriage, implantation failure and other complications. 

Recurrent implantation failure refers to women with three failed IVF attempts with good-quality embryos. Within the range of multiple risk factors, if there is evidence of certain levels of cytokine and specific autoantibodies, it hints that the immunological factor is responsible for the failure of the IVF cycle. Therefore, consulting with an IVF specialist who is knowledgeable in immunology may be beneficial in addressing this issue.

For instance, anti-nuclear antibodies, anti-cardiolipin antibodies (ACAs), and anti-phospholipid antibodies are some autoimmune antibodies that can cause pregnancy loss. Also, abnormal levels of cytokines can cause miscarriages. Cytokines are proteins produced by the white blood cells to manage inflammation in the body. Research states that elevated levels of TNF-α, a type of cytokine, increase the chances of miscarriage and harm pregnancy. Similarly, several autoimmune antibodies, such as anti-nuclear antibodies, anti-cardiolipin antibodies (ACAs), and anti-phospholipid antibodies, are involved in biochemical pregnancy loss.

The human immune system comprises natural killer cells, whose role in a pregnant woman is to provide a conducive environment for placentation and uneventful pregnancy, but a high count of natural killer cells can cause failed embryo implantation and miscarriage.

 Now let us learn the role of Intravenous immunoglobulin (IVIG) in such patients. As per research, intravenous immunoglobulin G (IVIG) can suppress high activity levels of autoimmune antibodies, reduce the destroying ability of NK cells and also inhibit cytokines. 

Dr. Nisarg Patel states that intravenous immunoglobulin G (IVIG) is administered through an intravenous drip in the arm at slow speeds, usually before embryo transfer and a couple of times after a positive pregnancy result. 

About Nisha IVF Center

Nisha IVF Bopal is a leading fertility clinic in Ahmedabad, India specializes in providing comprehensive reproductive services to couples and individuals struggling with infertility. The clinic is known for its state-of-the-art facilities, cutting-edge technology, and experienced team of fertility specialists.

Led by Dr Nisarg Patel, a renowned fertility specialist with over a decade of experience, Nisha IVF Bopal offers in vitro fertilization (IVF), intrauterine insemination (IUI), intracytoplasmic sperm injection (ICSI), egg freezing, surrogacy, and advanced techniques like time-lapse imaging, embryo glue, and pre-implantation genetic testing to improve the chances of success.

The clinic’s team of experienced embryologists, andrologists, nurses, and support staff are dedicated to providing personalized care and support to each patient, ensuring they receive the best possible treatment and achieve the best possible outcomes. Nisha IVF Bopal also offers counselling and support services to help patients overcome the emotional and psychological challenges of infertility.

With a track record of success and a commitment to excellence, Nisha IVF Bopal is a top choice for patients seeking fertility treatments in Ahmedabad and beyond. For more information mail: [email protected]


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